methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate

Base Information

• Chemical Name: methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate
• CAS No.: 1188325-56-5
• Molecular Formula: C₁₅H₁₆BrCl₂NO₃
• Molecular Weight: 409.107

Synonyms:methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate

Chemical Property of methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate

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Technology Process of methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate

There total 1 articles about methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoacetyl chloride (22118-09-8) + methyl 2-chloro-2-cyclopropylideneacetate (82979-45-1) + 4-chlorobenzylamine (104-86-9) → methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate (1188325-56-5)

Guidance literature:

methyl 2-chloro-2-cyclopropylideneacetate; 4-chlorobenzylamine; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

2-bromoacetyl chloride; With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 20 ℃; for 5h;

DOI:10.1039/b908548c

Reference yield: 99.0%

tryptamine (61-54-1) + methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate (1188325-56-5) → methyl 4-(4-chlorobenzyl)-7-[2-(1H-indol-3-yl)-ethyl]-5-oxo-4,7-diazaspiro[2.5]octane-8-carboxylate (1188325-74-7)

Guidance literature:

With triethylamine; In methanol; at 40 ℃; for 72h;

DOI:10.1039/b908548c

Reference yield: 90.0%

methyl 2-(1-(N-(4-chlorobenzyl)-2-bromoacetamido)-cyclopropyl)-2-chloroacetate (1188325-56-5) + isobutylamine (78-81-9) → methyl 4-(4-chlorobenzyl)-7-isobutyl-5-oxo-4,7-diaza-spiro[2.5]octane-8-carboxylate (1188325-65-6)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 72h;

DOI:10.1039/b908548c

upstream raw materials:

2-bromoacetyl chloride

methyl 2-chloro-2-cyclopropylideneacetate

4-chlorobenzylamine

Downstream raw materials:

methyl 4-(4-chlorobenzyl)-5-oxo-7-(2-trifluoromethyl benzyl)-4,7-diazaspiro[2.5]octane-8-carboxylate

methyl 4-(4-chlorobenzyl)-7-[2-(1H-indol-3-yl)-ethyl]-5-oxo-4,7-diazaspiro[2.5]octane-8-carboxylate

methyl 4-(4-chlorobenzyl)-7-naphthalen-2-ylmethyl-5-oxo-4,7-diazaspiro[2.5]octane-8-carboxylate

methyl 4-(4-chlorobenzyl)-5-oxo-7-(4-nitrobenzyl)-4,7-diazaspiro[2.5]octane-8-carboxylate

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