2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

Base Information

Chemical Name:2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole
CAS No.:127086-94-6
Molecular Formula:C₃₂H₃₁Cl₃N₂O₆
Molecular Weight:645.967
Hs Code.:

Synonyms:2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

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Chemical Property of 2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

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Technology Process of 2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

There total 10 articles about 2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 127086-79-7
2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-(trifluoroacetamido)oxazole

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 127086-94-6
2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ja00175a039

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127086-94-6
2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

3: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

4: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

5: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

6: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

7: 65 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; 18-crown-6 ether; sulfuric acid; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127086-94-6
2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<<(1b,1b,1b-trichloroethoxy)carbonyl>amino>oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

5: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

6: 65 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039