8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Base Information

Chemical Name:8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine
CAS No.:901124-79-6
Molecular Formula:C₂₀H₂₃BrN₄O
Molecular Weight:415.333
Hs Code.:

8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-<i>a</i>]pyridine

Synonyms:8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

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Chemical Property of 8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

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Technology Process of 8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

There total 2 articles about 8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 901124-75-2
8-bromo-2-(chloromethyl)-6-methylimidazo[1,2-a]pyridine

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 901124-79-6
8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Guidance literature:: With sodium carbonate; In ethanol; for 3h; Heating;
DOI:10.1021/jm060166w

Reference yield:

: 17282-00-7
3-bromo-5-methylpyridin-2-amine

: 901124-79-6
8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dimethoxy-ethane / 20 °C

1.2: 36 percent / ethanol / 2 h / Heating

2.1: 83 percent / Na₂CO₃ / ethanol / 3 h / Heating

With sodium carbonate; In 1,2-dimethoxyethane; ethanol;
DOI:10.1021/jm060166w

Reference yield: 54.0%

: 901124-79-6
8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

: 98-80-6
phenylboronic acid

: 2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-8-phenyl-imidazo[1,2-a]pyridine

Guidance literature:: With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 85 ℃; for 3h;
DOI:10.1021/jm060166w