N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Base Information

Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide
CAS No.:1240518-69-7
Molecular Formula:C₂₂H₂₃ClN₄O₃S₂
Molecular Weight:491.035
Hs Code.:

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

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Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

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Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

There total 1 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1240518-67-5
1,1-dimethylethyl ({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

: 75-16-1
methylmagnesium bromide

: 1240518-69-7
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: 1,1-dimethylethyl ({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water;

Reference yield: 5.0%

: 869681-70-9
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

: 64-18-6
formic acid

: 1240518-69-7
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

: 1240517-87-6
(3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxy-1-methylethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

Guidance literature:: (R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester; N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxy-1-methylethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.5h;

formic acid; In water; dimethyl sulfoxide; acetonitrile;