2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

Base Information

Chemical Name:2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole
CAS No.:884651-22-3
Molecular Formula:C₂₂H₂₇F₂NOSi
Molecular Weight:387.545
Hs Code.:

2-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1<i>H</i>-pyrrole

Synonyms:2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

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Chemical Property of 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

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Technology Process of 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

There total 3 articles about 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 884651-21-2
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 635724-41-3
tert-butyl 3-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2: 95 percent / TFA / CH₂Cl₂

With palladium diacetate; triphenyl-arsane; trifluoroacetic acid; In dichloromethane; 1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 133910-12-0
(1,1-dimethylethyl)(3-iodophenoxy)dimethylsilane

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2: 95 percent / TFA / CH₂Cl₂

With palladium diacetate; triphenyl-arsane; trifluoroacetic acid; In dichloromethane; 1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094