tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Base Information

Chemical Name:tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate
CAS No.:1263093-13-5
Molecular Formula:C₁₉H₂₂F₃NO₄
Molecular Weight:385.383
Hs Code.:

Synonyms:tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Suppliers and Price of tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

There total 7 articles about tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134302-07-1
tert-butyl 3-cyclopropyl-3-oxopropanoate

: 1263093-12-4
3-amino-2-methyl-4-(trifluoromethyl)benzoic acid

: 1263093-13-5
tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Guidance literature:: 3-amino-2-methyl-4-(trifluoromethyl)benzoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 22h;

tert-butyl 3-cyclopropyl-3-oxopropanoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 1263093-09-9
2-[3-fluoro-4-(trifluoromethyl)phenyl]-4,4-dimethyl-5H-oxazole

: 1263093-13-5
tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

2.2: 0.75 h / 140 °C

3.1: hydrogenchloride / water / 4 h / Reflux

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

4.2: 20 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; n-heptane; ISOPROPYLAMIDE; water;

Reference yield:

: 216144-68-2
3-fluoro-4-(trifluoromethyl)benzoyl chloride

: 1263093-13-5
tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 17.5 h / 5 - 25 °C

2.1: thionyl chloride / dichloromethane / 5 h / 20 °C

3.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

3.2: -70 - 20 °C

4.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

4.2: 0.75 h / 140 °C

5.1: hydrogenchloride / water / 4 h / Reflux

6.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

6.2: 20 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; n-heptane; dichloromethane; ISOPROPYLAMIDE; water;