(E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene

Base Information

• Chemical Name: (E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene
• CAS No.: 1109183-31-4
• Molecular Formula: C₁₁H₁₁F₂IO₃S
• Molecular Weight: 388.174
• Mol file: 1109183-31-4.mol

Synonyms:(E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene

Chemical Property of (E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene

There total 1 articles about (E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propargyl alcohol methyl ether (627-41-8) + [(difluoroiodomethyl)sulfonyl]benzene (802919-90-0) → (E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene (1109183-31-4) + (Z)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene

Guidance literature:

With air; triethyl borane; In hexane; dichloromethane; at -30 ℃; for 0.5h; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tet.2008.11.011

Reference yield: 94.0%

(E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene (1109183-31-4) + phenylacetylene (536-74-3) → (Z)-(5,5-difluoro-3-(methoxymethyl)-5-(phenylsulfonyl)pent-3-en-1-ynyl)benzene (1109183-61-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.tet.2008.11.011

Reference yield: 93.0%

(E)-(1,1-difluoro-3-iodo-4-methoxybut-2-enylsulfonyl)benzene (1109183-31-4) + hex-1-yne (693-02-7) → (Z)-(1,1-difluoro-3-(methoxymethyl)non-2-en-4-ynylsulfonyl)benzene (1109183-58-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.tet.2008.11.011

upstream raw materials:

propargyl alcohol methyl ether

[(difluoroiodomethyl)sulfonyl]benzene

Downstream raw materials:

(Z)-1-chloro-4-(4,4-difluoro-1-methoxy-4-(phenylsulfonyl)but-2-en-2-yl)benzene

((1E,3Z)-5,5-difluoro-3-(methoxymethyl)-5-(phenylsulfonyl)penta-1,3-dienyl)benzene

(Z)-(5,5-difluoro-3-(methoxymethyl)-5-(phenylsulfonyl)pent-3-en-1-ynyl)benzene

(Z)-(1,1-difluoro-3-(methoxymethyl)non-2-en-4-ynylsulfonyl)benzene