(S,S)-pseudoephedrine D-phenylalaninamide

Base Information

Chemical Name:(S,S)-pseudoephedrine D-phenylalaninamide
CAS No.:170899-07-7
Molecular Formula:C₁₉H₂₄N₂O₂
Molecular Weight:312.412
Hs Code.:

Synonyms:(S,S)-pseudoephedrine D-phenylalaninamide

Suppliers and Price of (S,S)-pseudoephedrine D-phenylalaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S)-pseudoephedrine D-phenylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S,S)-pseudoephedrine D-phenylalaninamide

There total 13 articles about (S,S)-pseudoephedrine D-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100-39-0
benzyl bromide

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

: 170899-07-7
(S,S)-pseudoephedrine D-phenylalaninamide

Guidance literature:: 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; at -78 - 0 ℃;

benzyl bromide; In tetrahydrofuran; at 0 ℃;
DOI:10.1071/CH03052

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 170899-07-7
(S,S)-pseudoephedrine D-phenylalaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, LiCl, 3.) aq. NaOH, 4.) aq. sodium bicarbonate

2: 1.) n-BuLi, LiCl

3: 1.) LDA, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h

With sodium hydroxide; n-butyllithium; sodium hydrogencarbonate; lithium chloride; lithium diisopropyl amide;
DOI:10.1021/ja00137a034

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 170899-07-7
(S,S)-pseudoephedrine D-phenylalaninamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 71 percent / n-BuLi; LiCl / 0 °C

2.1: LiOBu-t; tetra-n-butylammonium bromide / tetrahydrofuran / 0.5 h / 20 °C

2.2: aq. HCl / tetrahydrofuran / 20 °C

With n-butyllithium; tetrabutylammomium bromide; lithium chloride; lithium tert-butoxide; In tetrahydrofuran;
DOI:10.1016/S0957-4166(01)00027-1