3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

Base Information

Chemical Name:3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester
CAS No.:475481-47-1
Molecular Formula:C₂₂H₂₂O₄S
Molecular Weight:382.48
Hs Code.:

Synonyms:3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

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Chemical Property of 3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

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Technology Process of 3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

There total 1 articles about 3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 213455-35-7
4-benzyloxy-benzo[b]thiophene-7-carbaldehyde

: 16847-90-8
(1,2-diethoxy-2-oxoethyl)triphenylphosphonium chloride

: 475481-47-1
3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

Guidance literature:: In propanol, 2; at -20 - 20 ℃;

Reference yield: 99.0%

: 67-56-1
methanol

: 475481-47-1
3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

: 475481-48-2
[rac]-3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2-ethoxy-propionic acid methyl ester

Guidance literature:: 3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester; With magnesium; In tetrahydrofuran; methanol; at 20 - 50 ℃;

methanol; With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃; for 1h;

Reference yield:

: 475481-47-1
3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester

: [rac]-2-ethoxy-3-{4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran; methanol / 20 - 50 °C

1.2: 1 h / 25 °C

2.1: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 5 h / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 6 h / 0 - 20 °C

4.1: lithium hydroxide / 1,4-dioxane; water / 5 h / 20 °C

With lithium hydroxide; dimethylsulfide; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; magnesium; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;