di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Base Information

Chemical Name:di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate
CAS No.:913239-59-5
Molecular Formula:C₅₃H₆₉N₈O₁₄P
Molecular Weight:1073.15
Hs Code.:

di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Synonyms:di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Suppliers and Price of di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

There total 10 articles about di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 913239-32-4
[(N-benzyloxycarbonyl-O-tert-butyl)-D-seryl]-L-alanine

: 934622-42-1
di(4-acetamidophenyl) 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

: 913239-59-5
di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Guidance literature:: [(N-benzyloxycarbonyl-O-tert-butyl)-D-seryl]-L-alanine; With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane; for 0.166667h;

di(4-acetamidophenyl) 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm060622g

Reference yield:

: 934622-38-5
benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate

: 913239-59-5
di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / acetonitrile / Heating

2.1: H₂ / Pd/C / methanol / 8 h / 20 °C

3.1: HOBt; PS-carbodiimide / CH₂Cl₂ / 0.17 h

3.2: 40 percent / CH₂Cl₂ / 20 °C

With PS-carbodiimide; hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm060622g

Reference yield:

: 913239-30-2
di-(4-acetamidophenyl)-1-(benzyloxycarbonylamino)-2-(4-tert-butyloxycarbonylaminophenyl)ethanephosphonate

: 913239-59-5
di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: TFA / CH₂Cl₂ / 3 h / 20 °C

2.1: Et₃N / acetonitrile / Heating

3.1: H₂ / Pd/C / methanol / 8 h / 20 °C

4.1: HOBt; PS-carbodiimide / CH₂Cl₂ / 0.17 h

4.2: 40 percent / CH₂Cl₂ / 20 °C

With PS-carbodiimide; hydrogen; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm060622g