benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate

Base Information

• Chemical Name: benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate
• CAS No.: 934622-38-5
• Molecular Formula: C₃₂H₃₃N₄O₇P
• Molecular Weight: 616.61
• Mol file: 934622-38-5.mol

Synonyms:benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate

Chemical Property of benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate

There total 5 articles about benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-(4-acetamidophenyl)-1-(benzyloxycarbonylamino)-2-(4-tert-butyloxycarbonylaminophenyl)ethanephosphonate (913239-30-2) → benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate (934622-38-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm060622g

Reference yield:

tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate (104060-23-3) → benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate (934622-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

2: Cu(OTf)2 / CH₂Cl₂ / 4 h / 20 °C

3: TFA / CH₂Cl₂ / 3 h / 20 °C

With copper(II) bis(trifluoromethanesulfonate); Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; 1: Dess-Martin oxidation;

DOI:10.1021/jm060622g

Reference yield:

2-(4'-aminophenyl)ethyl alcohol (104-10-9) → benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate (934622-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / dioxane / 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

3: Cu(OTf)2 / CH₂Cl₂ / 4 h / 20 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

With copper(II) bis(trifluoromethanesulfonate); Dess-Martin periodane; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1021/jm060622g

upstream raw materials:

di-(4-acetamidophenyl)-1-(benzyloxycarbonylamino)-2-(4-tert-butyloxycarbonylaminophenyl)ethanephosphonate

tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate

2-(4'-aminophenyl)ethyl alcohol

4-(tert-butyloxycarbonylamino)phenylacetaldehyde

Downstream raw materials:

di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

di(4-acetamidophenyl) 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

di-(4-acetamidophenyl) 1-(benzyloxycarbonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate