(S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate
CAS No.:118474-95-6
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

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Chemical Property of (S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

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Technology Process of (S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

There total 13 articles about (S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2491-20-5
L-alanine methyl ester hydrochloride

: 35661-40-6
N-Fmoc L-Phe

: 118474-95-6
(S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Guidance literature:: N-Fmoc L-Phe; With 4-methyl-morpholine; 4-(4,6-di[2,2,2-trifluoroethoxy]-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate; In tetrahydrofuran; at 0 ℃; for 0.25h;

L-alanine methyl ester hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo2002038

Reference yield: 97.0%

: 126727-04-6
2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid

: 2491-20-5
L-alanine methyl ester hydrochloride

: 118474-95-6
(S)-methyl 2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Guidance literature:: With 4-methyl-morpholine; DMT*brucine tetrafluoroborate; brucine; In acetonitrile; at 0 - 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol802691x