4-phenylpentanenitrile

Base Information

• Chemical Name: 4-phenylpentanenitrile
• CAS No.: 107590-53-4
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.231
• Mol file: 107590-53-4.mol

Synonyms:4-phenylpentanenitrile

Chemical Property of 4-phenylpentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-phenylpentanenitrile

There total 13 articles about 4-phenylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Phenylethanol (98-85-1,13323-81-4) + acrylonitrile (107-13-1,25014-41-9) → 4-phenylpentanenitrile (107590-53-4)

Guidance literature:

With 2,4,6-trimethyl-pyridine; manganese; TiCl₄(2,4,6-collidine); In tetrahydrofuran; at 70 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02305

Reference yield: 85.0%

acetonitrile (75-05-8,26809-02-9) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 4-phenylpentanenitrile (107590-53-4)

Guidance literature:

With Ag/TiO₂; water; potassium hydroxide; at 20 ℃; for 24h; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Sealed tube; UV-irradiation; Green chemistry;

DOI:10.1039/d1gc00753j

Reference yield: 83.0%

2-Phenylpropanal (34713-70-7) + methyl 2-cyanoacetate (105-34-0) → 4-phenylpentanenitrile (107590-53-4)

Guidance literature:

With carbon monoxide; 5% rhodium-on-charcoal; water; In methanol; at 160 ℃; for 20h; under 38002.6 Torr; Autoclave;

DOI:10.1002/cctc.201500493

upstream raw materials:

1-bromo-3-phenylbutane

potassium cyanide

ethylbenzene

acrylonitrile

Downstream raw materials:

4-phenyl-1-pentanoic acid

2-methyl-4-phenylpentanenitrile

(R,S)-4-phenylvaleryl chloride

Refernces

• 1、 Afanasyev, Oleg I.,Zarochintsev, Alexander,Petrushina, Tatiana,Cherkasova, Anastasia,Denisov, Gleb,Cherkashchenko, Ilia,Chusova, Olga,Jinho, Oh,Man-Seog, Chun,Usanov, Dmitry L.,Semenov, Sergei E.,Chusov, Denis. "Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms". supporting information. p. 32 - 35. Retrieved 2018/12/05.
• 2、 Suga, Takuya,Shimazu, Shoma,Ukaji, Yutaka. "Low-Valent Titanium-Mediated Radical Conjugate Addition Using Benzyl Alcohols as Benzyl Radical Sources". supporting information. p. 5389 - 5392. Retrieved 2018/09/12.