(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

Base Information

Chemical Name:(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine
CAS No.:1455472-61-3
Molecular Formula:C₂₁H₃₈N₂OSi
Molecular Weight:362.631
Hs Code.:

Synonyms:(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

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Chemical Property of (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

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Technology Process of (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

There total 7 articles about (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1455472-60-2
(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)ethanol

: 74-89-5
methylamine

: 1455472-61-3
(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

Guidance literature:: (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)ethanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

methylamine; In dichloromethane; water; at 20 ℃;

Reference yield:

: 1455472-59-9
(1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol

: 1455472-61-3
(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 0 °C

2.1: ethanol / 80 °C

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 °C

3.2: 20 °C

With potassium carbonate; methanesulfonyl chloride; triethylamine; In methanol; ethanol; dichloromethane;

Reference yield:

: 5379-16-8
3,5-dimethylacetophenone

: 1455472-61-3
(S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; acetic acid; N-Bromosuccinimide / 3.5 h / 0 - 20 °C / Inert atmosphere

2.1: 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; borane N,N-diethylaniline complex; tert-butyl methyl ether / 4 h / 40 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 0 °C

4.1: ethanol / 80 °C

5.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 °C

5.2: 20 °C

With N-Bromosuccinimide; borane N,N-diethylaniline complex; 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; tert-butyl methyl ether; sulfuric acid; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In methanol; ethanol; dichloromethane;