Technology Process of (1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol
There total 3 articles about (1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
borane N,N-diethylaniline complex; 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; tert-butyl methyl ether;
at 40 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere
1.2: 2 h / 80 °C
2.1: sulfuric acid; acetic acid; N-Bromosuccinimide / 3.5 h / 0 - 20 °C / Inert atmosphere
3.1: 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; borane N,N-diethylaniline complex; tert-butyl methyl ether / 4 h / 40 °C / Inert atmosphere
With
N-Bromosuccinimide; borane N,N-diethylaniline complex; 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; tert-butyl methyl ether; sulfuric acid; iodine; magnesium; acetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid; acetic acid; N-Bromosuccinimide / 3.5 h / 0 - 20 °C / Inert atmosphere
2: 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; borane N,N-diethylaniline complex; tert-butyl methyl ether / 4 h / 40 °C / Inert atmosphere
With
N-Bromosuccinimide; borane N,N-diethylaniline complex; 3,3-diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole; tert-butyl methyl ether; sulfuric acid; acetic acid;
