((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

Base Information

Chemical Name:((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate
CAS No.:1187857-71-1
Molecular Formula:C₂₁H₂₄FNO₃
Molecular Weight:357.425
Hs Code.:

Synonyms:((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

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Chemical Property of ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

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Technology Process of ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

There total 8 articles about ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1187857-70-0
4-(dimethylamino)-1-((3-fluorophenyl)(phenyl)carbamoyl)pyridinium chloride

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

Guidance literature:: With pyridine; In acetonitrile; at 53 ℃; for 18h; Large scale;
DOI:10.1021/acs.jmedchem.6b00871

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate / toluene / 3 h / 105 °C / Large scale

2: pyridine / dichloromethane / 0 - 25 °C / Inert atmosphere; Large scale

3: acetonitrile / 20 - 25 °C / Large scale

4: pyridine / acetonitrile / 18 h / 53 °C / Large scale

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00871

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate / toluene / 3 h / 105 °C / Large scale

2: pyridine / dichloromethane / 0 - 25 °C / Inert atmosphere; Large scale

3: acetonitrile / 20 - 25 °C / Large scale

4: pyridine / acetonitrile / 18 h / 53 °C / Large scale

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00871