1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

Base Information

• Chemical Name: 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole
• CAS No.: 228259-30-1
• Molecular Formula: C₁₅H₉F₃N₂O₃
• Molecular Weight: 322.243
• Mol file: 228259-30-1.mol

Synonyms:1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

Chemical Property of 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

There total 1 articles about 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) + 2-hydrazino-benzoic acid (5326-27-2) → 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole (228259-30-1)

Guidance literature:

With acetic acid; for 6h; Heating;

DOI:10.1021/jm030212h

Reference yield: 100.0%

1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole (228259-30-1) → 2-(5-furan-2-yl-3-trifluoromethyl-pyrazol-1-yl)-benzoyl chloride

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 4h;

DOI:10.1021/jm030212h

Reference yield: 93.0%

conc. aqueous NH3 + 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole (228259-30-1) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide (228259-31-2)

Guidance literature:

In thionyl chloride; dichloromethane;

upstream raw materials:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

2-hydrazino-benzoic acid

Downstream raw materials:

3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine