2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine

Base Information

• Chemical Name: 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine
• CAS No.: 228259-33-4
• Molecular Formula: C₁₅H₁₂F₃N₃O
• Molecular Weight: 307.275
• Mol file: 228259-33-4.mol

Synonyms:2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine

Chemical Property of 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine

There total 7 articles about 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile (228259-32-3) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine (228259-33-4)

Guidance literature:

With sodium tetrahydroborate; CoCl₂; In N,N-dimethyl-formamide;

Reference yield:

cobalt chloride + 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile (228259-32-3) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine (228259-33-4)

Guidance literature:

With hydrogenchloride; sodium borohydrid; In methanol; N,N-dimethyl-formamide;

Reference yield:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine (228259-33-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

With ammonium hydroxide; sodium tetrahydroborate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030212h

upstream raw materials:

2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

2-hydrazino-benzoic acid

1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

Downstream raw materials:

1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

{2-[5-(2'-methanesulfonyl-biphenyl-4-yl-carbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

1-[2-([(t-butoxycarbonyl)amino]methyl)phenyl]-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-3-(trifluoromethyl)pyrazole

{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester