2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide

Base Information

• Chemical Name: 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide
• CAS No.: 228259-31-2
• Molecular Formula: C₁₅H₁₀F₃N₃O₂
• Molecular Weight: 321.259
• Mol file: 228259-31-2.mol

Synonyms:2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide

Chemical Property of 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide

There total 5 articles about 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

conc. aqueous NH3 + 1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole (228259-30-1) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide (228259-31-2)

Guidance literature:

In thionyl chloride; dichloromethane;

Reference yield:

2-(5-furan-2-yl-3-trifluoromethyl-pyrazol-1-yl)-benzoyl chloride → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide (228259-31-2)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/jm030212h

Reference yield:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) → 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide (228259-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With ammonium hydroxide; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm030212h

upstream raw materials:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

2-hydrazino-benzoic acid

1-(2-carboxyphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

Downstream raw materials:

{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

1-[2-([(t-butoxycarbonyl)amino]methyl)phenyl]-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-3-(trifluoromethyl)pyrazole

{2-[5-(2'-methanesulfonyl-biphenyl-4-yl-carbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester