methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

Base Information

• Chemical Name: methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate
• CAS No.: 1421921-01-8
• Molecular Formula: C₂₄H₂₇N₃O₂S
• Molecular Weight: 421.563
• Mol file: 1421921-01-8.mol

Synonyms:methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

Chemical Property of methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

There total 5 articles about methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl N-formyl-N-methylglycinate (68892-06-8) + 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide (1421922-08-8) → methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate (1421921-01-8)

Guidance literature:

methyl N-formyl-N-methylglycinate; With oxalyl dichloride; In chloroform; at 20 ℃; for 0.166667h; Inert atmosphere;

2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide; In chloroform; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide (1421922-04-4) → methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate (1421921-01-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

3.1: oxalyl dichloride / chloroform / 0.17 h / 20 °C / Inert atmosphere

3.2: 1.5 h / 20 °C / Inert atmosphere

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; In methanol; chloroform; isopropyl alcohol;

Reference yield:

2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide (1421922-07-7) → methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate (1421921-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

2.1: oxalyl dichloride / chloroform / 0.17 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 20 °C / Inert atmosphere

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; In methanol; chloroform;

upstream raw materials:

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

(2,5-dimethylphenyl)acetonitrile

(2,5-dimethyl-4-nitrophenyl)acetonitrile