Methyl 2-(N-methylformamido)acetate

Base Information

• Chemical Name: Methyl 2-(N-methylformamido)acetate
• CAS No.: 68892-06-8
• Molecular Formula: C5H9 N O3
• Molecular Weight: 131.131
• Hs Code.: 2924199090
• European Community (EC) Number: 272-594-1
• DSSTox Substance ID: DTXSID8071805
• Nikkaji Number: J332.668C
• Wikidata: Q81999601
• Mol file: 68892-06-8.mol

Synonyms:Methyl 2-(N-methylformamido)acetate;68892-06-8;Glycine, N-formyl-N-methyl-, methyl ester;methyl 2-[formyl(methyl)amino]acetate;Methyl N-formyl-N-methylglycinate;N-Formyl-N-methylglycine methyl ester;EINECS 272-594-1;n-formyl sarcosine methyl ester;SCHEMBL1247150;DTXSID8071805;Methyl2-(N-methylformamido)acetate;MFCD20529543;AKOS014324011;Glycine,N-forMyl-N-Methyl-,Methyl ester;F17500;A866952;StratoSpheres(TM) PL-DMA resin, 60-270 mesh, extent of labeling: 1.0 mmol/g loading, 1 % cross-linked

Chemical Property of Methyl 2-(N-methylformamido)acetate

Chemical Property:

• Vapor Pressure: 0.0264mmHg at 25°C
• Boiling Point: 246.9°C at 760 mmHg
• Flash Point: 103.1°C
• PSA: 46.61000
• Density: 1.1g/cm³
• LogP: -0.11650
• Storage Temp.: 2-8°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.058243149
• Heavy Atom Count: 9
• Complexity: 113

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(N-methylformamido)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(=O)OC)C=O

Technology Process of Methyl 2-(N-methylformamido)acetate

There total 4 articles about Methyl 2-(N-methylformamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formic acid (64-18-6) + N-methylglycine methyl ester hydrochloride (13515-93-0) → methyl N-formyl-N-methylglycinate (68892-06-8)

Guidance literature:

With sodium formate; for 2h; Ambient temperature;

DOI:10.1055/s-1988-27702

Reference yield: 81.0%

N-methylglycine methyl ester hydrochloride (13515-93-0) + formic acid ethyl ester (109-94-4) → methyl N-formyl-N-methylglycinate (68892-06-8)

Guidance literature:

With potassium carbonate; In ethanol; at 20 ℃;

Reference yield: 54.0%

Methyl formate (107-31-3) + N-methylglycine methyl ester hydrochloride (13515-93-0) → methyl N-formyl-N-methylglycinate (68892-06-8)

Guidance literature:

With potassium carbonate; In methanol; for 26h;

DOI:10.1002/cmdc.201600417

upstream raw materials:

formic acid

N-methylglycine methyl ester hydrochloride

formic acid ethyl ester

Methyl formate

Downstream raw materials:

1-methyl-5-carbomethoxy-2-thio-imidazole

methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

α-N-methyltryptophan