N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide

Base Information

• Chemical Name: N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide
• CAS No.: 82390-46-3
• Molecular Formula: C₁₂H₁₆ClNO₃
• Molecular Weight: 257.717
• Mol file: 82390-46-3.mol

Synonyms:N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide

Chemical Property of N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide

There total 3 articles about N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-methoxybenzoic acid (3438-16-2) → N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide (82390-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1.) room temperature, 0.5 h, 2.) reflux, 0.5 h

2: 145 mg / CH₂Cl₂ / 20 h / Ambient temperature

With thionyl chloride; In dichloromethane;

DOI:10.1021/ja00229a037

Reference yield:

methyl 5-chloro-2-methoxybenzoate (33924-48-0) → N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide (82390-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 10 percent sodium hydroxide / 16 h / Ambient temperature

2: thionyl chloride / 1.) room temperature, 0.5 h, 2.) reflux, 0.5 h

3: 145 mg / CH₂Cl₂ / 20 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In dichloromethane;

DOI:10.1021/ja00229a037

Reference yield:

2-Amino-2-methyl-1-propanol (124-68-5) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → N-<2-(2-methyl-1-hydroxypropyl)>-2-methoxy-5-chlorobenzamide (82390-46-3)

Guidance literature:

In dichloromethane; at 25 ℃; for 3h; Yield given;

DOI:10.1021/jo00140a012

upstream raw materials:

2-Amino-2-methyl-1-propanol

2-methoxy-5-chlorobenzoyl chloride

5-chloro-2-methoxybenzoic acid

methyl 5-chloro-2-methoxybenzoate

Downstream raw materials:

9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

2-(4-Chloro-2'-methyl-biphenyl-2-yl)-3,4,4-trimethyl-4,5-dihydro-oxazol-3-ium; iodide

5-chloro-2-fluoro-2-(2-bromomethylphenyl)benzophenone

(4-Chloro-2'-methyl-biphenyl-2-yl)-(2-fluoro-phenyl)-methanol