tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

Base Information

Chemical Name:tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate
CAS No.:1445985-38-5
Molecular Formula:C₂₉H₃₄Cl₂N₂O₄
Molecular Weight:545.506
Hs Code.:

Synonyms:tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

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Chemical Property of tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

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Technology Process of tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

There total 13 articles about tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1445985-07-8
tert-butyl 3-[4-(bromomethyl)-2,5-dichlorophenyl]-propanoate

: 1445984-83-7
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-hydroxycyclopropyl)methanone

: 1445985-38-5
tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 30 ℃;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445985-38-5
tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

Guidance literature:: Multi-step reaction with 6 steps

1: chromium(VI) oxide; sulfuric acid; acetic anhydride; acetic acid / 6 h / 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: rhodium contaminated with carbon; hydrogen / ethyl acetate / 20 °C

5: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran; dichloromethane / 2 h / 20 °C

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-38-5
tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

With borane-THF; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;