4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Base Information

• Chemical Name: 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
• CAS No.: 226397-54-2
• Molecular Formula: C₂₃H₂₇NO₆S₂
• Molecular Weight: 477.602

Synonyms:4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Chemical Property of 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Chemical Property:

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Technology Process of 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

There total 5 articles about 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate (226397-38-2) → 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (226397-54-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; for 20h; Heating;

DOI:10.1021/jm0500875

Reference yield:

1-tert-butyl 4-ethyl 4-[(4-fluorophenyl)thio]piperidine-1,4-dicarboxylate (226396-62-9) → 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (226397-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / MCPBA / CH₂Cl₂ / 20 h / 0 °C

2: 91 percent / K₂CO₃ / dimethylformamide / 36 h / 20 °C

3: 60 percent / aq. NaOH / ethanol; tetrahydrofuran / 20 h / Heating

With sodium hydroxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0500875

Reference yield:

1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate (226396-63-0) → 4-(4-phenylsulfanyl-benzenesulfonyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (226397-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / dimethylformamide / 36 h / 20 °C

2: 60 percent / aq. NaOH / ethanol; tetrahydrofuran / 20 h / Heating

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0500875

upstream raw materials:

1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

1-tert-butyl 4-ethyl 4-[(4-fluorophenyl)thio]piperidine-1,4-dicarboxylate

1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate

bis(4-fluorophenyl)disulfide

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