4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

Base Information

Chemical Name:4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline
CAS No.:1394166-10-9
Molecular Formula:C₂₃H₂₄FN₃O₅
Molecular Weight:441.459
Hs Code.:

Synonyms:4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

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Chemical Property of 4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

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Technology Process of 4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

There total 15 articles about 4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 733724-68-0
4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

: 403-19-0
2-fluoro-4-nitrophenol

: 1394166-10-9
4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

Guidance literature:: In chlorobenzene; at 140 ℃; for 30h;
DOI:10.1016/j.bmc.2013.04.013

Reference yield: 82.0%

: 479690-08-9
1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline

: 1394166-10-9
4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

Guidance literature:: 1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline; With potassium carbonate; at 20 ℃; for 0.5h;

1-(3-halopropyl)pyrrolidine;; at 70 ℃; for 4h;
DOI:10.1016/j.ejmech.2020.112174

Reference yield:

: 1428788-17-3,205448-56-2
6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-ol

: 1394166-10-9
4-(2-fluoro-4-nitrophenyloxy)-6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 6 h / 85 °C

2: chlorobenzene / 30 h / 140 °C

With trichlorophosphate; In chlorobenzene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013 DOI:10.1016/j.ejmech.2013.04.001 DOI:10.1016/j.bmc.2014.05.013