2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Base Information

Chemical Name:2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene
CAS No.:303176-44-5
Molecular Formula:C₂₅H₁₉FN₂O₉
Molecular Weight:510.432
Hs Code.:

Synonyms:2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Suppliers and Price of 2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

There total 10 articles about 2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 303176-43-4
1-[6-fluoro-(2R)-3,4-dihydro-2H-benzopyran-2-yl]-(1S)-1,2-ethylene glycol

: 62-23-7
4-nitro-benzoic acid

: 303176-44-5
2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Guidance literature:: With thiamine diphosphate; diethylazodicarboxylate; In tetrahydrofuran; at -20 - 20 ℃;
DOI:10.1016/S0040-4020(00)00572-X

Reference yield:

: 371-41-5
4-Fluorophenol

: 303176-44-5
2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Guidance literature:: Multi-step reaction with 10 steps

1.1: 83 percent / K₂CO₃ / acetone / 8 h / Heating

2.1: 76 percent / 6 h / 210 °C

3.1: 84 percent / imidazole / CH₂Cl₂ / 10 h / 20 °C

4.1: BH₃*DMS / tetrahydrofuran / 1.5 h / 10 °C

4.2: 75 percent / 30 percent H₂O₂ / 2 h / 0 °C

5.1: Dess-Martin periodinane; PhCO₂H / CH₂Cl₂; dimethylsulfoxide / 0.5 h

6.1: 4.4 g / CH₂Cl₂; dimethylsulfoxide / 10 h / 20 °C

7.1: 78 percent / DIBAL-H / CH₂Cl₂; hexane / 0 - 20 °C

8.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

9.1: 65 percent / (-)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C

10.1: 61 percent / DEAD; TPP / tetrahydrofuran / -20 - 20 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; thiamine diphosphate; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; (-)-diethyl tartrate; benzoic acid; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Alkylation / 2.1: Claisen rearrangement / 3.1: silylation / 4.1: hydroboration / 4.2: Oxidation / 5.1: Oxidation / 6.1: Wittig olefinatiom / 7.1: Reduction / 8.1: desilylation / 9.1: Cyclization / 10.1: Esterification;
DOI:10.1016/S0040-4020(00)00572-X

Reference yield:

: 13990-72-2
1-allyloxy-4-fluorobenzene

: 303176-44-5
2-(1,2-di(4-nitrophenylcarbonyloxy)-(1R)-ethyl)-6-fluoro-(2R)-3H,4H-chromene

Guidance literature:: Multi-step reaction with 9 steps

1.1: 76 percent / 6 h / 210 °C

2.1: 84 percent / imidazole / CH₂Cl₂ / 10 h / 20 °C

3.1: BH₃*DMS / tetrahydrofuran / 1.5 h / 10 °C

3.2: 75 percent / 30 percent H₂O₂ / 2 h / 0 °C

4.1: Dess-Martin periodinane; PhCO₂H / CH₂Cl₂; dimethylsulfoxide / 0.5 h

5.1: 4.4 g / CH₂Cl₂; dimethylsulfoxide / 10 h / 20 °C

6.1: 78 percent / DIBAL-H / CH₂Cl₂; hexane / 0 - 20 °C

7.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

8.1: 65 percent / (-)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C

9.1: 61 percent / DEAD; TPP / tetrahydrofuran / -20 - 20 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; thiamine diphosphate; diisobutylaluminium hydride; Dess-Martin periodane; (-)-diethyl tartrate; benzoic acid; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 1.1: Claisen rearrangement / 2.1: silylation / 3.1: hydroboration / 3.2: Oxidation / 4.1: Oxidation / 5.1: Wittig olefinatiom / 6.1: Reduction / 7.1: desilylation / 8.1: Cyclization / 9.1: Esterification;
DOI:10.1016/S0040-4020(00)00572-X