[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

Base Information

Chemical Name:[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester
CAS No.:157487-64-4
Molecular Formula:C₄₃H₅₅N₇O₁₂
Molecular Weight:861.949
Hs Code.:

[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

Synonyms:[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

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Chemical Property of [2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

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Technology Process of [2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

There total 8 articles about [2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 157487-64-4
[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 32.6 g / AcCl / Heating

2: NBS, benzoyl-peroxide / CCl₄ / Heating

3: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

4: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

5: SOCl₂, DMF / 2 h / Ambient temperature

6: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

7: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

8: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

With potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; triethylamine; acetyl chloride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 157487-64-4
[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NBS, benzoyl-peroxide / CCl₄ / Heating

2: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

3: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

4: SOCl₂, DMF / 2 h / Ambient temperature

5: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

6: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

7: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

With potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88071-91-4
5-bromomethyl-2-nitrobenzoic acid methyl ester

: 157487-64-4
[2-(2-{2-[2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

2: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

3: SOCl₂, DMF / 2 h / Ambient temperature

4: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

5: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

6: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

With potassium hydroxide; sodium hydroxide; thionyl chloride; Aliquat; hydrogen; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide;