diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

Base Information

Chemical Name:diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate
CAS No.:897650-20-3
Molecular Formula:C₁₅H₂₀F₂NO₆P
Molecular Weight:379.297
Hs Code.:

Synonyms:diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

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Chemical Property of diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

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Technology Process of diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

There total 2 articles about diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 15050-24-5
N-(benzyloxycarbonyl)glycyl chloride

: 82845-20-3
[(diethoxyphosphoryl)difluoromethyl]zinc bromide

: 897650-20-3
diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

Guidance literature:: With copper(I) bromide; In 1,2-dimethoxyethane; at 20 ℃; for 4h;
DOI:10.1021/jo060364v

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 897650-20-3
diethyl 3-(N-benzyloxycarbonyl)amino-1,1-difluoro-2-oxopropylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₅ / 1,2-dimethoxy-ethane / 0.5 h / 0 °C

2: 6 percent / CuBr / 1,2-dimethoxy-ethane / 4 h / 20 °C

With phosphorus pentachloride; copper(I) bromide; In 1,2-dimethoxyethane;
DOI:10.1021/jo060364v