(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

Base Information

Chemical Name:(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol
CAS No.:404961-36-0
Molecular Formula:C₁₅H₂₁NO₅
Molecular Weight:295.335
Hs Code.:

Synonyms:(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

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Chemical Property of (3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

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Technology Process of (3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

There total 11 articles about (3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 404961-35-9
Acetic acid 4-((3aR,4R,8R,8aR)-4,8-dihydroxy-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulen-6-yl)-phenyl ester

: 404961-36-0
(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0960-894X(01)00719-3

Reference yield:

: 3969-84-4
3,4-di-O-isopropylidene-D-mannitol

: 404961-36-0
(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 4 h / 0 °C

2: K₂CO₃ / methanol / 2.5 h / 25 °C

3: H₂O / 95 °C

4: aq. NaOH / methanol

With pyridine; sodium hydroxide; potassium carbonate; In methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2005.11.090

Reference yield:

: 3969-59-3
mannitol triacetonide

: 404961-36-0
(3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol

Guidance literature:: Multi-step reaction with 5 steps

1: aq. AcOH

2: pyridine / CH₂Cl₂ / 4 h / 0 °C

3: K₂CO₃ / methanol / 2.5 h / 25 °C

4: H₂O / 95 °C

5: aq. NaOH / methanol

With pyridine; sodium hydroxide; potassium carbonate; acetic acid; In methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2005.11.090