6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

Base Information

• Chemical Name: 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester
• CAS No.: 373638-25-6
• Molecular Formula: C₂₂H₂₅NO₅
• Molecular Weight: 383.444
• Mol file: 373638-25-6.mol

Synonyms:6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

Chemical Property of 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

There total 8 articles about 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester (350014-20-9) → 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester (373638-25-6)

Guidance literature:

3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 23 - 40 ℃; for 2.66667h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

m-tyramine (588-05-6) → 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester (373638-25-6)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. HCl

2: TMSiCl

3: Et₃N

4: NaH

5: NaOH

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; sodium hydride; triethylamine;

DOI:10.1016/j.bmcl.2005.02.040

Reference yield:

rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (91523-50-1) → 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester (373638-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1: TMSiCl

2: Et₃N

3: NaH

4: NaOH

With sodium hydroxide; chloro-trimethyl-silane; sodium hydride; triethylamine;

DOI:10.1016/j.bmcl.2005.02.040

upstream raw materials:

3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester

m-tyramine

rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester

Downstream raw materials:

1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

1-[[[(R)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester

1-[[[(S)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester

6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide