(1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane

Base Information

• Chemical Name: (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane
• CAS No.: 7637-11-8
• Molecular Formula: C₁₂H₂₂O
• Molecular Weight: 182.306
• Mol file: 7637-11-8.mol

Synonyms:(1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane

Chemical Property of (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane

There total 19 articles about (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(1S,2R,5S)-(+)-menthol (15356-60-2) + calcium carbide (75-20-7) → (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane (7637-11-8)

Guidance literature:

(1S,2R,5S)-(+)-menthol; calcium carbide; With potassium fluoride; potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h;

With water; In dimethyl sulfoxide; at 130 ℃; for 3h; Sealed tube;

DOI:10.1039/c7gc00724h

Reference yield: 88.0%

rac-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl vinyl ether → menthol (89-78-1) + (1S,2R,4R)-1-isopropyl-4-methyl-(2-vinyloxy)cyclohexane (5989-48-0,7637-09-4,7637-10-7,7637-11-8,23960-73-8,46173-76-6,127642-93-7,3885-03-8) + (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane (7637-11-8)

Guidance literature:

With water; C₂H₃O₂^(1-)*C₃₆H₅₃CoN₂O₂⁽¹⁺⁾; In methanol; at -10 ℃; for 2h; Product distribution / selectivity;

Reference yield: 88.0%

rac-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl vinyl ether → menthol (89-78-1) + (1S,2R,4R)-1-isopropyl-4-methyl-(2-vinyloxy)cyclohexane (5989-48-0,7637-09-4,7637-10-7,7637-11-8,23960-73-8,46173-76-6,127642-93-7,3885-03-8) + (1R,2S,4S)-1-isopropyl-4-methyl-2-(vinyloxy)cyclohexane (7637-11-8)

Guidance literature:

With water; C₂H₃O₂^(1-)*C₃₆H₅₃CoN₂O₂⁽¹⁺⁾; In methanol; at -10 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

(-)-menthol

acetylene

butan-1-ol

ethyl vinyl ether

Downstream raw materials:

acetaldehyde