1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline
CAS No.:59224-75-8
Molecular Formula:C₂₂H₂₁NO
Molecular Weight:315.415
Hs Code.:
DSSTox Substance ID:DTXSID401189803
Nikkaji Number:J543.039I

Synonyms:1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline;DTXSID401189803;Methyl 4-(2-phenyl-1,2,3,4-tetrahydro-1-isoquinolinyl)phenyl ether #;59224-75-8

Suppliers and Price of 1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:315.162314293
Heavy Atom Count:24
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2C3=CC=CC=C3CCN2C4=CC=CC=C4

Technology Process of 1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline

There total 12 articles about 1,2,3,4-Tetrahydro-1-(4-methoxyphenyl)-2-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3340-78-1
2-phenyl-1,2,3,4-tetrahydroisoquinoline

: C₇H₇BrOZn*MgCl₂*LiCl

: 59224-75-8
1-(4-methoxyphenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 2-phenyl-1,2,3,4-tetrahydroisoquinoline; With bis-[(trifluoroacetoxy)iodo]benzene; In 2-methyltetrahydrofuran; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

C₇H₇BrOZn*MgCl₂*LiCl; In 2-methyltetrahydrofuran; at 20 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1055/s-0036-1589029

Reference yield: 78.0%

: 3340-78-1
2-phenyl-1,2,3,4-tetrahydroisoquinoline

: 459-64-3
4-methoxybenzenediazonium tetrafluoroborate

: 59224-75-8
1-(4-methoxyphenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 2-phenyl-1,2,3,4-tetrahydroisoquinoline; With N-hydroxyphthalimide; 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen; In acetonitrile; at 20 ℃; for 0.25h; Irradiation;

4-methoxybenzenediazonium tetrafluoroborate; In acetonitrile; at 20 ℃; for 6h; Solvent; Reagent/catalyst; Time; Catalytic behavior; Irradiation;
DOI:10.1002/asia.202000999

Reference yield: 64.0%

: 3340-78-1
2-phenyl-1,2,3,4-tetrahydroisoquinoline

: 5720-07-0
4-methoxyphenylboronic acid

: 59224-75-8
1-(4-methoxyphenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tert.-butylhydroperoxide; copper(I) bromide; In 1,2-dimethoxyethane; at 95 ℃; Inert atmosphere;
DOI:10.1021/ol8012588