N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

Base Information

Chemical Name:N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide
CAS No.:1189175-91-4
Molecular Formula:C₃₀H₃₈F₄N₂O₄S₂Si
Molecular Weight:658.854
Hs Code.:

N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

Synonyms:N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

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Chemical Property of N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

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Technology Process of N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

There total 4 articles about N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1535-65-5
difluoromethyl phenyl sulfone

: 1283090-77-6
N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

: 1189175-91-4
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: difluoromethyl phenyl sulfone; N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1189175-91-4
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; titanium(IV) tetraethanolate; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 1017599-17-5
(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone

: 1189175-91-4
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; titanium(IV) tetraethanolate; lithium hexamethyldisilazane; In tetrahydrofuran;