N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

Base Information

Chemical Name:N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide
CAS No.:1283090-77-6
Molecular Formula:C₂₃H₃₂F₂N₂O₂SSi
Molecular Weight:466.668
Hs Code.:

Synonyms:N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

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Chemical Property of N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

There total 3 articles about N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189175-69-6
(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1283090-77-6
N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone; (S)-2-methylpropane-2-sulfinamide; With titanium(IV) tetraethanolate; In tetrahydrofuran; Reflux;

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 1017599-17-5
(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone

: 1283090-77-6
N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

With 1H-imidazole; titanium(IV) tetraethanolate; In tetrahydrofuran;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1283090-77-6
N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

With 1H-imidazole; titanium(IV) tetraethanolate; In tetrahydrofuran;