Synonyms:lyxose;lyxose, (D)-isomer;lyxose, (L)-isomer
98%, *data from raw suppliers
D-Lyxose *data from reagent suppliers
There total 89 articles about (2S,3S,4R)-2,3,4,5-tetrahydroxypentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 61.0%
Reference yield:
The study reports the synthesis of 3-substituted L-fuco-azafagomines from D-lyxose, representing the first example of aza-C-glycosides with a biimino moiety. These compounds are potential selective inhibitors of a-L-fucosidases, enzymes involved in the biosynthetic processing of fucose-containing glycoconjugates and associated with various physiological and pathological events. The key step in the synthesis involves reductive hydrazination of a 1-deoxy-ketohexose with tert-butyl carbazate. The synthesized compounds, 3a and 3b, were tested for their inhibitory activities against twelve glycosidases, with 3a showing selective and competitive inhibition of a-L-fucosidase from bovine kidney. The study highlights the potential of these compounds as leads for developing new therapeutic agents targeting a-L-fucosidases.
The study investigates the synthesis of seven-membered ring glycals through endo-selective alkynol cycloisomerization catalyzed by tungsten carbonyl. The researchers used alkynyldiols as substrates, which undergo cycloisomerization to form the corresponding seven-membered cyclic enol ethers with good yields and virtually complete regioselectivity favoring endo-mode cyclization. The study began with the conversion of D-ribose into alkynyl alcohol precursors, which were then used to produce alkynyldiols. The unexpected regioselectivity for seven-membered ring formation is likely due to the presence of the dioxolane structure tethering the terminal alkyne and diol functional groups. The study demonstrated that this transformation is general for various diastereomers of acetonide-protected alkynyldiols derived from different sugars, including D-lyxose, D-xylose, and L-arabinose. The availability of these septanose glycals could significantly advance the synthesis of structurally unusual hexoseptanose glycosides.
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