1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide

Base Information

• Chemical Name: 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide
• CAS No.: 266338-66-3
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 266338-66-3.mol

Synonyms:1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide

Chemical Property of 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide

There total 1 articles about 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Tropic acid (529-64-6,28845-94-5) + 3'-(Dimethylamino)spiroazirin> (108805-12-5) → 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide (266338-66-3)

Guidance literature:

In acetonitrile; at 20 ℃; for 48h;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

Reference yield: 99.0%

1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide (266338-66-3) → 1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-cyclopentanecarboxilic acid (266338-69-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

Reference yield:

1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-N,N-dimethylcyclopentanecarboxamide (266338-66-3) → 1-(1-{1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]cyclopentanecarboxamido}cyclopentanecarboxamido)cyclopentanecarboxilic acid (266338-84-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / aq. HCl / tetrahydrofuran / 24 h / 20 °C

2: 90 percent / acetonitrile / 25 h / 20 °C

3: 100 percent / aq. HCl / tetrahydrofuran / 26 h / 20 °C

4: 92 percent / acetonitrile / 72 h / 20 °C

5: 95 percent / aq. HCl / tetrahydrofuran / 4.5 h / 40 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile; 1: Hydrolysis / 2: Addition / 3: Hydrolysis / 4: Addition / 5: Hydrolysis;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

upstream raw materials:

Tropic acid

3'-(Dimethylamino)spiroazirin>

Downstream raw materials:

1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-cyclopentanecarboxilic acid

1-{1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]cyclopentanecarboxamido}cyclopentanecarboxilic acid

1-{1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]cyclopentanecarboxamido}-N,N-dimethylcyclopentanecarboxamide

1-(1-{1-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]cyclopentanecarboxamido}cyclopentanecarboxamido)cyclopentanecarboxilic acid