Technology Process of C18H23NO5
There total 1 articles about C18H23NO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl N-benzyloxycarbonyl-L-pyroglutamate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 1h;
methyl trifluoromethanesulfonate;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 3h;
With
water; ammonium chloride;
In
tetrahydrofuran; toluene;
DOI:10.1016/j.tetlet.2010.11.058
- Guidance literature:
-
C18H23NO5;
With
lithium triethylborohydride;
In
tetrahydrofuran;
at -78 ℃;
for 1.5h;
Inert atmosphere;
With
water; sodium hydrogencarbonate;
In
tetrahydrofuran;
DOI:10.1016/j.tetlet.2010.11.058
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium triethylborohydride / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere
2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2.75 h / -78 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C
5: triethylamine; trifluoroacetic anhydride / dichloromethane / 2 h / 0 °C
6: palladium on carbon; hydrogen / tetrahydrofuran / 12 h / 760.05 Torr
7: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran
8: palladium on carbon; hydrogen / ethyl acetate / 24 h / 760.05 Torr
With
triethylsilane; 1-hydroxy-7-aza-benzotriazole; palladium on carbon; boron trifluoride diethyl etherate; hydrogen; lithium triethylborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2010.11.058
