ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

Base Information

• Chemical Name: ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate
• CAS No.: 299937-04-5
• Molecular Formula: C₂₂H₁₈N₂O₅
• Molecular Weight: 390.395
• Mol file: 299937-04-5.mol

Synonyms:ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

Chemical Property of ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

There total 3 articles about ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-nitro-benzaldehyde (99-61-6) + ethyl 2-cyanoacetate (105-56-6) + β-naphthol (135-19-3) → ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate (299937-04-5)

Guidance literature:

With sodium malonate; In water; at 70 ℃; for 1.08333h; Green chemistry;

DOI:10.1007/s11164-017-3011-7

Reference yield: 83.0%

ethanol (64-17-5) + C25H26N3O5(1+)*Cl(1-) → ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate (299937-04-5) + choline chloride (67-48-1)

Guidance literature:

With diethylamine; at 40 ℃; for 10h;

DOI:10.1002/cjoc.201190023

Reference yield:

C8H15N2O2(1+)*Cl(1-) (64992-15-0) → ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate (299937-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / water / 8 h / 80 °C

2: diethylamine / 10 h / 40 °C

With piperidine; diethylamine; In water;

DOI:10.1002/cjoc.201190023

upstream raw materials:

3-nitro-benzaldehyde

ethyl 2-cyanoacetate

β-naphthol

ethanol