Base Information
- Chemical Name:CID 522265
- CAS No.:67-48-1
- Molecular Formula:C5H14ClNO
- Molecular Weight:139.625
- Hs Code.:2923.10
- Mol file:67-48-1.mol
Synonyms:
Synonyms:
99.0%Min *data from raw suppliers
Choline chloride 98% *data from reagent suppliers
Xi
There total 43 articles about CID 522265 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 98.0%
Reference yield: 88.0%
Reference yield: 84.0%
The research investigates a novel catalytic system for the one-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles using cetyltrimethylammonium bisulphate ([CTA]HSO4) generated in situ from cetyltrimethylammonium peroxodisulphate (CTAPS) in a choline chloride–urea deep eutectic solvent (DES). The purpose is to develop an efficient, environmentally friendly, and cost-effective method for synthesizing 1,3,4-oxadiazoles, which are important heterocycles used in various fields such as medicines, pesticides, and dyes. The study concludes that this method offers several advantages over traditional procedures, including milder reaction conditions, simplicity in workup and purification, good to excellent yields, and the use of inexpensive, recyclable reagents.
The study presents a novel method for synthesizing N,N-disubstituted hydroxylamines from secondary amines using choline peroxydisulfate (ChPS) as an oxidizing agent. ChPS, a task-specific ionic liquid, is synthesized from choline chloride and potassium persulfate. It acts as an environmentally benign and biodegradable oxidant, enabling the selective oxidation of a wide variety of secondary amines to their corresponding hydroxylamines in a rapid, one-step reaction under mild conditions (RT to 60 °C for 1 hour). The method is notable for its operational simplicity, high selectivity, and green reaction conditions. The study explores the oxidation of various secondary amines, including aliphatic, aromatic, and heterocyclic compounds, yielding N,N-disubstituted hydroxylamines in moderate to good yields (up to 96%). The products are characterized using 1H NMR and 13C NMR spectroscopy. The proposed mechanism involves nucleophilic attack by the secondary amine on ChPS, leading to the cleavage of O–O and O–S bonds and the formation of hydroxylamines. This method is particularly useful for oxidizing complex amines and offers a practical and efficient alternative to traditional oxidation methods, which often suffer from issues such as reagent instability, low yields, and harsh reaction conditions.
This research aims to develop a green and efficient method for the Friedel-Crafts acylation of aromatic compounds and five-membered heterocycles. The study utilizes [CholineCl][ZnCl2]3, a deep eutectic solvent formed between choline chloride and ZnCl2, as a dual-function catalyst and green solvent. This approach eliminates the need for moisture-sensitive Lewis acids and volatile organic solvents traditionally used in such reactions. The reactions are carried out under microwave irradiation, resulting in high yields and short reaction times for the synthesis of ketones. Notably, indole derivatives can be regioselectively acylated in the 3-position under mild conditions without NH protection, yielding three new ketone products.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
