4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Base Information

Chemical Name:4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline
CAS No.:1259522-04-7
Molecular Formula:C₂₅H₃₂FNOSSi
Molecular Weight:441.685
Hs Code.:

Synonyms:4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Suppliers and Price of 4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Chemical Property:

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Technology Process of 4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

There total 9 articles about 4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-(2-ethyl-6-fluoro-3-phenylquinolin-4-ylthio)ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1259522-04-7
4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 2h;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 371-40-4
4-fluoroaniline

: 1259522-04-7
4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 60 °C

2: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

3: N,N-dimethyl-formamide / 16 h / 100 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h

With 1H-imidazole; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259522-04-7
4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 16 h / 100 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h

With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001