2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

Base Information

Chemical Name:2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid
CAS No.:518344-02-0
Molecular Formula:C₃₄H₃₃NO₇
Molecular Weight:567.639
Hs Code.:

Synonyms:2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

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Chemical Property of 2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

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Technology Process of 2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

There total 7 articles about 2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 518344-01-9
2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-ethoxycarbonyl-1-methyl-ethoxy)-phenoxy]-butyric acid ethyl ester

: 518344-02-0
2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 7h;
DOI:10.1021/jo026655v

Reference yield:

: 42806-90-6
2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester

: 518344-02-0
2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 83.9 percent / K₂CO₃; sodium sulfate / ethanol / 10 h / Heating

2.1: NaH / dimethylformamide / 1.5 h / 20 °C

2.2: 89 percent / dimethylformamide / 70 °C

3.1: aq. NaOH / ethanol / 0.75 h / Heating

3.2: 63 percent / conc. HCl / ethanol / 16 h / pH 1 / Heating

4.1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

5.1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

With sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; sodium sulfate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo026655v

Reference yield:

: 100-52-7
benzaldehyde

: 518344-02-0
2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

3: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

With sodium hydroxide; sodium tris(acetoxy)borohydride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo026655v