(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

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Chemical Name:(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate
CAS No.:1381926-83-5
Molecular Formula:C₃₀H₃₅F₂NO₆
Molecular Weight:543.608
Hs Code.:

Synonyms:(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

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Chemical Property of (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

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Technology Process of (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

There total 2 articles about (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 1381926-83-5
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 5538-51-2
O-acetylsalicyloyl chloride

: 1381926-83-5
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.01.024