4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

Base Information

Chemical Name:4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine
CAS No.:1353579-43-7
Molecular Formula:C₂₉H₃₅NO₅
Molecular Weight:477.601
Hs Code.:

Synonyms:4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

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Chemical Property of 4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

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Technology Process of 4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

There total 4 articles about 4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1353579-41-5
(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(3-(hydroxymethyl)-2-methoxypyridin-4-yl)propan-1-ol

: 100-39-0
benzyl bromide

: 1353579-43-7
4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

Guidance literature:: (S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(3-(hydroxymethyl)-2-methoxypyridin-4-yl)propan-1-ol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo201974f

Reference yield:

: 1353579-39-1
(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-ethyl-4-methoxyfuro[3,4-c]pyridin-3(1H)-one

: 1353579-43-7
4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 70 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo201974f

Reference yield:

: 16498-81-0
2-methoxynicotinic acid

: 1353579-43-7
4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.2: 4 h / 70 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/jo201974f