(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

Base Information

Chemical Name:(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid
CAS No.:1201830-89-8
Molecular Formula:C₂₅H₂₇NO₅
Molecular Weight:421.493
Hs Code.:

Synonyms:(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

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Chemical Property of (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

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Technology Process of (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

There total 6 articles about (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201830-88-7
(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanal

: 1201830-89-8
(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

Guidance literature:: (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanal; With sodium dihydrogenphosphate; In 2-methyl-but-2-ene; water; acetonitrile; for 0.5h;

With sodium chlorite; In 2-methyl-but-2-ene; water; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jo201974f

Reference yield:

: 1353579-39-1
(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-ethyl-4-methoxyfuro[3,4-c]pyridin-3(1H)-one

: 1201830-89-8
(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 70 °C / Inert atmosphere

3.1: hydrogenchloride; water / methanol / 2 h / 20 °C

4.1: sodium periodate / water; acetonitrile / 2 h / 20 °C

5.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h

5.2: 2 h / 20 °C

With hydrogenchloride; sodium periodate; sodium dihydrogenphosphate; lithium aluminium tetrahydride; water; sodium hydride; In tetrahydrofuran; methanol; 2-methyl-but-2-ene; water; acetonitrile;
DOI:10.1021/jo201974f

Reference yield:

: 1353579-41-5
(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(3-(hydroxymethyl)-2-methoxypyridin-4-yl)propan-1-ol

: 1201830-89-8
(S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: hydrogenchloride; water / methanol / 2 h / 20 °C

3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C

4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h

4.2: 2 h / 20 °C

With hydrogenchloride; sodium periodate; sodium dihydrogenphosphate; water; sodium hydride; In tetrahydrofuran; methanol; 2-methyl-but-2-ene; water; acetonitrile;
DOI:10.1021/jo201974f