4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

Base Information

Chemical Name:4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid
CAS No.:1610861-31-8
Molecular Formula:C₂₀H₃₀N₂O₇S
Molecular Weight:442.533
Hs Code.:

Synonyms:4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

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Chemical Property of 4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

Chemical Property:

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Technology Process of 4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

There total 7 articles about 4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610861-32-9
methyl 4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)-ethylsulfonamido)-3-(cyclopropylmethoxy)benzoate

: 1610861-31-8
4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

Guidance literature:: With water; lithium hydroxide; at 20 ℃; for 24h;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1610861-31-8
4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / water / 144 h / 60 °C

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 775.74 Torr

4: pyridine / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 1 h / 20 °C

6: dmap / dichloromethane / 1 h / 20 °C

7: water; lithium hydroxide / 24 h / 20 °C

With pyridine; dmap; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; potassium iodide; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1610861-31-8
4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)ethylsulfonamido)-3-(cyclopropylmethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 775.74 Torr

3: pyridine / dichloromethane / 1 h / 0 - 20 °C

4: ethanol / 1 h / 20 °C

5: dmap / dichloromethane / 1 h / 20 °C

6: water; lithium hydroxide / 24 h / 20 °C

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; potassium iodide; lithium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;