trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

Base Information

Chemical Name:trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane
CAS No.:1342897-19-1
Molecular Formula:C₁₄H₁₇F₃O₂Si
Molecular Weight:302.368
Hs Code.:

Synonyms:trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

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Chemical Property of trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

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Technology Process of trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

There total 2 articles about trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 75-77-4
chloro-trimethyl-silane

: 1342897-24-8
3-(2-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

: 1342897-19-1
trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

Guidance literature:: 3-(2-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 20 - 25 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201100995

Reference yield:

: 3038-48-0
2-(trifluoromethyl)phenylacetic acid

: 1342897-19-1
trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

1.2: 12.17 h / -78 °C / Inert atmosphere; Reflux

1.3: 1 h / 0 °C / Inert atmosphere; Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / 20 - 25 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1002/chem.201100995

Reference yield:

: 1342897-19-1
trimethyl((3-(2-(trifluoromethyl)phenyl)-4,5-dihydrofuran-2-yl)oxy)silane

: 123-62-6
propionic acid anhydride

: 1342897-35-1
3-propionyl-3-(2-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

Guidance literature:: With 3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at 20 - 25 ℃; Inert atmosphere;
DOI:10.1002/chem.201100995