1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole
• CAS No.: 108429-52-3
• Molecular Formula: C₉H₁₁N₃O₂
• Molecular Weight: 193.205
• Mol file: 108429-52-3.mol

Synonyms:1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

Chemical Property of 1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

There total 1 articles about 1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methoxy-phenylazide (2101-87-3) + acetaldehyde (75-07-0,9002-91-9) → 1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole (108429-52-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, room temp., 16 h; 2.) THF, 15 deg C, 24 h;

DOI:10.1016/S0040-4020(01)87546-3

Reference yield: 14.0%

1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole (108429-52-3) → 4-methoxyformanilide (5470-34-8) + 4-methoxy-aniline (104-94-9) + 1-(4-methoxyphenyl)-1H-[1,2,3]triazole (68535-49-9)

Guidance literature:

With Lithium enolate of the acetaldehyde; In tetrahydrofuran; for 20h; Heating;

DOI:10.1016/S0040-4020(01)87546-3

Reference yield:

1-(p-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole (108429-52-3) → 1-(4-methoxyphenyl)-1H-[1,2,3]triazole (68535-49-9)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 1.5h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)87546-3

upstream raw materials:

p-methoxy-phenylazide

acetaldehyde

Downstream raw materials:

4-methoxyformanilide

4-methoxy-aniline

1-(4-methoxyphenyl)-1H-[1,2,3]triazole