(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Base Information

Chemical Name:(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane
CAS No.:1056675-31-0
Molecular Formula:C₃₄H₃₇NO₄
Molecular Weight:523.672
Hs Code.:

Synonyms:(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Suppliers and Price of (1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

There total 5 articles about (1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1056675-27-4
3-(4-methoxytrityloxymethyl)benzonitrile

: 24424-99-5
di-tert-butyl dicarbonate

: 75-16-1
methylmagnesium bromide

: 1056675-31-0
(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Guidance literature:: 3-(4-methoxytrityloxymethyl)benzonitrile; methylmagnesium bromide; In tetrahydrofuran; iethyl e; at 0 - 60 ℃; for 2.83333h;

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h; Heating / reflux;

di-tert-butyl dicarbonate; With methanol; sodium hydroxide; water; more than 3 stages;

Reference yield:

: 1056675-35-4
C₂₉H₂₉NO₂

: 24424-99-5
di-tert-butyl dicarbonate

: 1056675-31-0
(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Guidance literature:: In ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmcl.2010.10.140

Reference yield:

: 874-97-5
3-(hydroxymethyl)benzonitrile

: 1056675-31-0
(1R,S)-1-(t-butoxycarbonylamino)-1-(3-(4-methoxytrityloxymethyl)phenyl) ethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 20 °C

2.1: tetrahydrofuran; diethyl ether / 2.5 h / 0 - 60 °C

2.2: 2 h / 0 - 20 °C / Heating / reflux

3.1: ethyl acetate / 20 °C

With pyridine; In tetrahydrofuran; diethyl ether; ethyl acetate;