2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID
• CAS No.: 866133-65-5
• Molecular Formula: C₁₄H₉FN₂O₂
• Molecular Weight: 256.236
• Hs Code.: 2933998090
• Mol file: 866133-65-5.mol

Synonyms:2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid

Chemical Property of 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine-6-carboxylic acid ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID

There total 3 articles about 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866133-01-9) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid (866133-65-5)

Guidance literature:

With hydrogen bromide; In acetic acid; at 120 ℃; for 10h;

Reference yield:

methyl 6-aminonicotinoate (36052-24-1) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid (866133-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 8.5 h / Heating / reflux

2: hydrogen bromide / acetic acid / 10 h / 120 °C

With hydrogen bromide; In 1,4-dioxane; acetic acid;

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid (866133-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 8.5 h / Heating / reflux

2: hydrogen bromide / acetic acid / 10 h / 120 °C

With hydrogen bromide; In 1,4-dioxane; acetic acid;

upstream raw materials:

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester

methyl 6-aminonicotinoate

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid tert-butylamide

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