METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Base Information

• Chemical Name: METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
• CAS No.: 866133-01-9
• Molecular Formula: C₁₅H₁₁FN₂O₂
• Molecular Weight: 270.263
• Hs Code.: 2933998090
• Mol file: 866133-01-9.mol

Synonyms:2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester

Chemical Property of METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-(4-fluorophenyl)imidazo[1,2-a]pyridine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

There total 2 articles about METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 6-aminonicotinoate (36052-24-1) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866133-01-9)

Guidance literature:

In 1,4-dioxane; for 8.5h; Heating / reflux;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866133-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate / 80 °C / Inert atmosphere

2: sodium carbonate / ethanol / 70 °C

With sodium carbonate; copper(ll) bromide; In ethanol; ethyl acetate;

DOI:10.1016/j.bmc.2020.115574

Reference yield: 38.0%

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866133-01-9) → 2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid (866133-65-5)

Guidance literature:

With hydrogen bromide; In acetic acid; at 120 ℃; for 10h;

upstream raw materials:

methyl 6-aminonicotinoate

2-bromo-4'-fluoroacetophenone

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid

2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid tert-butylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 866133-01-9 METHYL 2-(4-FLUOROPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send